Nolvadex (tamoxifen) has been specially designed for the needs of people with breast cancer. It is often prescribed to reduce the risk of breast cancer in females likely to develop this disease - either because of their age or other factors. Make sure you discuss your treatment with your health care provider. This is especially important if you need to take Nolvadex for 5 years (for prevention of breast cancer). Your health care provider will need to know if you have a history of cataract, high triglycerides, a history of stroke or blood clot, or liver disease, or if you are taking such drugs as aminoglutethimide, antibiotics, letrozole, antidepressants, pioglitazone, nicardipine, bromocriptine, heart rhythm medications, cimetidine, isoniazid, HIV or AIDS medicines, rifampin, blood thinners, or anti-malaria medications. Interactions are possible when the drugs mentioned and Nolvadex are sued together, so you will need to take that fact into consideration. Side effects are common, especially while your body needs to adjust to the dose prescribed. The following ones are most likely: increased tumor pain, hot flashes, nausea, thinning of hair, depression, headache, stomach cramps, constipation, excessive tiredness, weight loss, and dizziness.